Applications of carbon nanotubes in biotechnology and. A nanometer is onebillionth of a meter, or about one tenthousandth of the thickness of a human hair. The development of nanomedicine is based primarily on the development of smart and multifunctional nanomaterials that can serve under the different clusters including drug delivery systems, diagnostics, and regenerative medicine. Applications in pharmacy and medicine huahe, 1,2 lienaiphamhuy, 3 pierredramou, 1 delixiao, 1 penglizuo, 1 andchuongphamhuy 4 china pharmaceutical university, nanjing, china key laboratory of drug quality control and pharmacovigilance, ministry of education, china pharmaceutical university, nanjing, china. Introduction since carbon nanotubes cnts were discover ed by iijima in 1991iijima, 1991, they have become the subject of many studies because of. Carbon nanotubes, due to their large surface areas, unique surface properties, and needlelike shape, can deliver a large amount of therapeutic agents, including dna and sirnas, to the target. Their impressive structural, mechanical, and electronic properties are due to their small size and mass, their strong mechanical potency, and their high electrical and thermal conductivity. Carbon nanotubes as a novel drug delivery system for anticancer therapy. The advances of carbon nanotubes in cancer diagnostics and. Highresolution electron microscope image of a single multiwalled carbon nanotube mwcnt penetrating out of the lung surface into the pleural space. Carbon nanotubes often refer to singlewall carbon nanotubes swcnts with diameters in the range of a nanometer.
Early scientific studies have indicated that some of these nanoscale particles may pose a greater health risk than the larger bulk form of these materials. These slides use concepts from my jeff funk course entitled analyzing hitech opportunities to analyze how the economic feasibility of carbon nanotubes is becoming better through developing new forms of carbon nanotubes, new methods of synthesis, and increasing the scale of production equipment. They can be thought of as a sheet of graphite a hexagonal lattice of carbon rolled into a cylinder. Introduction carbon nanostructures like fullerenes, graphene and nanotubes are of great interest for the current research as well as for future industrial applications. Due to their nanoscale dimensions, electron transport in carbon nanotubes will take place through quantum effects and will only propagate along the axis of the tube. Potentials and limitations, syntheses and applications of carbon nanotubes and their composites, satoru suzuki, intechopen, doi. Carbon nanotubes in nanomedicine karolinska institutet. Bharati vidyapeeths college of pharmacy, sec8, cbd belapur. Drug delivery much promising is the use of nanotubes as carriers transporting biologically active drugs to certain welldefined sites. In the article carbon nanotubes, the synthesis, structure, properties, and potential applications of multiwalled and singlewalled variants of carbon were discussed extensively.
Carbon nanotubes cnts are very prevalent in todays world of medical research and are being highly researched in the fields of efficient drug delivery and biosensing methods for disease treatment and health monitoring. Sumio iijima who is credited with the discovery of carbon nanotubes. Among various nanomaterials involved in nanomedicine, carbon nanotubes cnts. National science and technology council, committee on technology subcommittee on nanoscale science, engineering, and technology national nanotechnology coordination oice 4201 wilson blvd. Carbon nanotube, singlewalled print date msds document number page 3 of 8 september 2, 2014 swnt01e 4 first aid measures eye contact. The nanotubes would effectively stop the bullet from penetrating the body, although the bullets kinetic energy would likely cause broken bones and internal bleeding. Although the strength of individual cnt shells is extremely high, weak shear interactions between adjacent shells and tubes lead to significant reduction in the effective strength of multiwalled carbon nanotubes and carbon nanotube bundles down to only a few gpa. Among all the nanomaterials, a material by name carbon nanotubes has led the way in terms of its captivating structure and also its ability to furnish specific applications ranging from the electronics to the energy. Carbon nanotubes list of high impact articles ppts. Toxicological and pharmacological studies suggest guidelines for the safe use of carbon nanotubes in medicine. He spend three years of postdoctoral research at the fundamental research laboratory of nec corporation in tsukuba japan, working with dr. Carbon nanotubes cnts are allotropes of carbon, made of graphite and constructed in cylindrical tubes with nanometer in diameter and several millimeters in length. Cnts can be used as drugdelivery vehicles or nanocarriers in cancer therapy and other areas of medicine without causing toxicity to healthy tissue while allowing prolonged release of the drug tasis et al.
Since carbon nanotubes are currently an area of active research the books on the subject tend to be aimed at a research audience. This book presents the key computational modeling and numerical simulation tools to investigate carbon nanotube characteristics. Current and potential applications of carbon nanotubes. Eatemadi, a daraee, h karimkhanloo, h kouhi, m zarghami, n. Carbon nanotubes as optical sensors in biomedicine. An overview of the recent progress in the synthesis and. Over the past many decades there has been a sudden growth in the field of research and advancement related to the nanomaterials. Introduction to carbon nanotubes carbon nanotubes were discovered in 1991 by sumio iijima of nec and are effectively long, thin cylinders of graphite, which you will be familiar with as the material in a pencil or as the basis of some lubricants. Present and future commercial applications michael f. Potential applications of carbon nanotubes wikipedia. Cnt, which have been constructed with lengthtodiameterratio of up to 2,000,000. Amongst various reported drug delivery vehicles, cnts are. Singlewalled carbon nanotubes 205 dices determine whether a swnt will be a metal or a semiconductor. Potential benefits and risks of nanotechnology in nuclear medicine downloading may take up to 30 seconds.
Carbon nanotubes can also enable shorter processing times and higher energy efficiencies during composite curing with the use of carbon nanotube structured heaters. A whole range of issues from the preparation, structure, properties and observation of quantum effects in carbon nanotubes in comparison with 0 d fullerenes are discussed. Thus, some nanotubes have conductivities higher than that of copper, while others behave more like silicon. In vitro and in vivo detection, imaging and drug delivery zhuang liu, scott tabakman, kevin welsher, and hongjie dai department of chemistry, stanford university, ca 94305, usa. The cylindrical carbon molecules feature high aspect ratios lengthtodiameter values typically above 10 3, with diameters from about 1 nanometer up to tens of nanometers and lengths up to millimeters. Graphite is made up of layers of carbon atoms arranged in a hexagonal lattice, like chicken wire see. Applications of carbon nanotubes in biotechnology and biomedicine. Carbon nanotubes cnts are tubes made of carbon with diameters typically measured in nanometers. Review article carbon nanotubes and its applications. Carbon nanotube technology has shown to have the potential to alter drug delivery and biosensing methods for the better, and thus, carbon nanotubes have recently garnered. Pdf rapid development in the field of nanomedicine is bringing novel opportunities for improved. Carbon nanotubes top journals a carbon nanotube is a tubeshaped material, made of carbon, having a diameter measuring on the nanometer scale. Due to their electrical, chemical, mechanical and thermal properties, carbon nanotubes are one of the most promising materials for the electronics, computer and aerospace industries.
Carbon nanomaterials for biological and medical applications. Recently, carbon nanotubes cnts have received enormous attention due to their extraordinary properties. Physical properties of carbon nanotubes by saito, dresselhaus and dresselhaus imperial college press, 1998. Many different production methods for carbon nanotubes cnts have been introduced. Carbon nanotubes in biomedicine and biosensing yingyue zhu, libing wang and chuanlai xu jiangnan university, china 1. Types, methods of preparation and applications parijat pandey, mandeep dahiya department of pharmaceutical sciences, maharshi dayanan d university, rohtak, har yana, india. Potentials and limitations wei shao, paul arghya, mai yiyong, laetitia rodes and satya prakash additional information is available at the end of the chapter. In this issue of the journal of nuclear medicine, mcdevitt et al. Wei shao, paul arghya, mai yiyong, laetitia rodes and satya prakash may 9th 20. Drug delivery with carbon nanotubes for in vivo cancer. Drug delivery with carbon nanotubes for in vivo cancer treatment zhuang liu1, kai chen2, corrine davis3, sarah sherlock1, qizhen cao2, xiaoyuan chen2, hongjie dai1 1 department of chemistry, stanford university, stanford, ca 94305, usa 2 the molecular imaging program at stanford mips, department of radiology, biophysics and biox. Targeted drug delivery with cnts requires conjugation of both targeting molecules and drug molecules to the same nanotube, and thus requires carefully. The nanotubes consisted of up to several tens of graphitic shells socalled multiwalled carbon nanotubes mwnts with adjacent shell separation of 0.
Carbon nanotubes cnts, one of the unique onedimensional nanomaterials, have gained great attention because of their specific characters, versatile functionalization chemistry, and biological compatibility in the past few decades. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. Singlewalled carbon nanotubes lieber research group. Shahryarighoshekandi 1department of chemistry, science and research branch, islamic azad university, tehran, iran 2young researchers and elite club, science and research branch, islamic azad university, tehran, iran. If the slide opens in your browser, select file save as to save it. Department of laboratory medicine clinical research center carbon nanotubes in nanomedicine doctoral dissertation thesis for doctoral degree ph. Carbon nanotubes as a novel drug delivery system for. Nanotubes are categorized as singlewalled nanotubes. Synthesis of carbon nanotubes fb physik, fu berlin. Carbon nanotubes cnts are a class of carbon allotropes with interesting.
Key laboratory of drug quality control and pharmacovigilance, ministry of education, china pharmaceutical university, nanjing 29, china. Among various nanomaterials involved in nanomedicine, carbon nanotubes cnts possessing a unique onedimensional structure with interesting intrinsic mechanical, physical, and chemical properties have been extensively explored for a wide range of. Investigation into their properties has become one of the most active fields of modern research. These are large macromolecules that are unique for their size, shape, and remarkable physical properties. Targeting of tumors with radionuclides for radiotherapeutic purposes is often limited by inadequate delivery to lesions using currently available targeting vehicles e. Carbon nanotubes top journals omics international journal. Application in medicine the application of nanotubes in medicine is related to the possibility of their biofunctionalization and the control of their biocompatibility 21,22. Immediately flush eyes gently and thoroughly, including under the eyelids, with clean running water. This unique onedimensional structure and concomitant properties endow carbon nanotubes with special. Introduction since carbon nanotubes cnts were discover ed by iijima in 1991iijima, 1991, they have become the subject of many studies because of their unique electrical, optical, thermal, and. Pdf carbon nanotubes for drug delivery researchgate. Applications of carbon nanotubes in pharmacy and medicine. Carbon nanotubes carbon nanotubes, long, thin cylinders of carbon, were discovered in 1991 by sumio iijima. Carbon nanotubes in medicine medical applications for carbon nanotubes in range from sensors for early detection of imflammatory disease to building lenses that can concentrate sound waves enough to blast diseased tissue from outside the patients body.
Functionalization of carbon nanotubes and its application. Drug delivery with carbon nanotubes for in vivo cancer treatment. The long and short of carbon nanotube toxicity nature. Carbon nanotubes cnts are cylindrical large molecules consisting of a hexagonal arrangement of hybridized carbon atoms, which may by formed by rolling up a single sheet of graphene singlewalled carbon nanotubes, swcnts or by rolling up multiple sheets of graphene multiwalled carbon nanotubes, mwcnts.
Since iijima first discovered carbon nanotubes cnts in. Nanomaterials for biological and medical applications explores the different applications of carbon nanomaterials in drug and gene therapies and their use in tissue regeneration, biosensor diagnosis, enantiomer separation of chiral drugs, extraction and analysis of drugs and pollutants, and as antitoxents. Cnts have been used in various areas of biomedicine as nanocarriers. Nanomaterials for biological and medical applications explores the different applications of carbon nanomaterials in drug and gene therapies and their use in tissue regeneration, biosensor diagnosis, enantiomer separation of chiral drugs, extraction and analysis of drugs and pollutants, and as antitoxents the book describes the synthesis processing of carbon nanomaterials, carbon composite. Carbon nanotubes cnts possess outstanding properties and a unique physicochemical architecture, which may serve as an alternative platform for the delivery of various therapeutic molecules.
Carbon nanotube, also called buckytube, nanoscale hollow tubes composed of carbon atoms. Carbon nanotubes are even being used to enhance sporting goods like tennis rackets, baseball bats, and bicycle frames. Occupational exposure to carbon nanotubes and nanofibers 2. In continuation of the previous work, this article addresses the key issues on hand in carbon nanotube technology. For those of you who would like to read more about carbon nanotubes i can recommend two books. Biology and medicine are rapidly emerging as new areas for the application of cnts. They were discovered independently by iijima and ichihashi and bethune et al. Cnts can be functionalized via different methods to perform their specific functions. Because carbon nanotubes are highly electrically conductive, they have the ability to be a costeffective replacement for metal wires. They hold promise for applications in medicine, gene, and drug delivery areas. Prospects for the use of carbon nanotubes in medicine. Mar 01, 2005 the first published observation of carbon nanotubes in 1991 7 stimulated significant interest and research, leading to rapid progress in the field. Diameters of the carbon nanotubes have ranging from. Realizing the promise of carbon nanotubes national science.
Bharati vidyapeeths college of pharmacy, sec8, cbd belapur, navi mumbai 400 614 m. Carbon nanotubes have many structures, differing in length, thickness, and in the type of helicity and number of layers. Carbon nanotubes show a unique combination of stiffness, strength, and tenacity compared to other fiber materials which usually lack one or more of these properties. Carbon nanotubes as nanocarriers in medicine sciencedirect. John hart4,5 worldwide commercialinterest in carbon nanotubes cnts is reflectedin aproduction capacity that presently. Pdf rapid development in the field of nanomedicine is bringing novel opportunities. Carbon nanotubes have been studied extensively in relation to fullerenes, and together with fullerenes have opened a new science and technology field on nano scale materials.